In clinical studies on aripiprazole for the treatment of schizophrenia, people taking the medication experienced improvements in their schizophrenia symptoms, including hallucinations and suspiciousness, compared to those not taking it. Longer studies also showed that the drug can help keep symptoms from returning.
Clinical studies have also shown aripiprazole to be effective for bipolar disorder treatment. In these studies, the medication was effective at treating episodes of mania or mixed episodes (involving both mania and depression). It also helped prevent bipolar disorder symptoms from returning.
Aripiprazole has also been studied for treating major depression (when used along with antidepressants). These studies evaluated people who had not responded adequately to antidepressants alone. Adding aripiprazole significantly reduced depression symptoms, compared to adding a placebo (a “sugar pill” with no active ingredient).
Researchers have also studied aripiprazole for treating irritability associated with autism in children (age 6 through 17 years old). In these studies, children taking aripiprazole showed improvement in their irritability symptoms (aggression towards others, deliberate self-harm, temper tantrums, and quickly changing moods), compared to children taking a placebo.