Chlorpromazine Dosing

For those who are being treated for schizophrenia or mania symptoms with chlorpromazine, dosing typically starts at 10 mg three or four times daily or 25 mg two or three times daily. For the treatment of severe nausea and vomiting, the suggested starting dosage is 10 mg to 25 mg every four to six hours as needed. Your age and weight are among the factors that can affect the chlorpromazine dose your healthcare provider recommends.

An Introduction to Chlorpromazine Dosing

The dose of chlorpromazine hydrochloride (Thorazine®) that your healthcare provider recommends will vary depending on a number of factors, including:
 
  • The medical condition being treated
  • Your age and weight
  • Other medical conditions you may have
  • Other medications you may be currently taking.
     
As always, do not adjust your chlorpromazine dose unless your healthcare provider specifically instructs you to do so.
 
Chlorpromazine Dosing for Schizophrenia or Mania
The recommended starting chlorpromazine dose for schizophrenia or mania is 10 mg three or four times daily or 25 mg two or three times a day. If your schizophrenia is especially severe (and you are hospitalized), your healthcare provider may choose to start you at a higher dose. If necessary, your healthcare provider may increase your chlorpromazine dosage.
 
Chlorpromazine Dosing for Nausea and Vomiting
The recommended dose of chlorpromazine for severe nausea and vomiting is 10 mg to 25 mg every four to six hours as needed.
 
Pre-surgical Chlorpromazine Dosing
The recommended chlorpromazine dose for the relief of restlessness or worry before a surgery is 25 mg to 50 mg taken two or three hours before the surgery.

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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