Drug Interactions With Chlorpromazine

Interactions With Chlorpromazine Explained

The following sections explain in detail the potentially negative interactions that can occur when chlorpromazine is combined with any of the drugs listed above.
 
Alcohol
In general, people taking chlorpromazine should avoid alcohol (see Alcohol and Thorazine).
 
Barbiturates
Chlorpromazine should not be combined with large doses of barbiturates, due to the increased risk of sedation and other problems.
 
Certain Anticonvulsants
Taking chlorpromazine with certain anticonvulsants (seizure medications) can increase your risk of drowsiness and seizures. Talk with your healthcare provider before using these medications together.
 
Certain SSRI Antidepressants
Taking chlorpromazine with certain SSRI antidepressants can raise the amount of chlorpromazine in your blood, increasing your risk of chlorpromazine side effects. If you are taking these drugs together, your healthcare provider may need to decrease your chlorpromazine dosage.
 
Narcotics and Opiates
Chlorpromazine should not be combined with large doses of narcotics or opiates, due to the increased risk of sedation and other problems.
 
Pindolol
Combining chlorpromazine with pindolol may raise the amount of both medications in your blood, increasing your risk of side effects. Talk with your healthcare provider before using these medications together.
 
Propranolol (Inderal, Inderal LA, InnoPran XL)
Combining chlorpromazine with propranolol may raise the amount of both medications in your blood, increasing your risk of side effects. Talk with your healthcare provider before using these medications together.
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