Side Effects of Chlorpromazine

Side Effects of Chlorpromazine to Report

There are a number of side effects of chlorpromazine that you should report to your healthcare provider. These include but are not limited to:
  • A painful erection of the penis that does not go away (priapism)
  • Yellowing of the eyes or skin (jaundice), which may be signs of liver damage
  • Any signs of an infection (since chlorpromazine can cause low levels of white blood cells, which can increase your risk of infections)
  • Dizziness or fainting when standing or sitting up suddenly
  • An irregular heart rhythm (arrhythmia)
  • Changes in walking patterns
  • Breast changes, including breast enlargement or breast discharge
  • Very severe constipation
  • Worsening of psychotic symptoms
  • Unusual body, facial, or tongue movements
  • Muscle tension or contractions
  • Feelings of internal restlessness or jitteriness
  • Seizures
  • Signs or symptoms of neuroleptic malignant syndrome (NMS), which can include:


    • A high fever
    • Stiff muscles
    • Confusion
    • Irregular pulse or blood pressure
    • An increased heart rate (tachycardia)
    • Sweating
    • Irregular heart rhythms (arrhythmias)


  • Signs of an allergic reaction, including unexplained rash, hives, itching, unexplained swelling, wheezing, or difficulty breathing or swallowing.

A Summary of Side Effects of Chlorpromazine

It is possible that you may experience some or none of these side effects of chlorpromazine explained above. Unfortunately, there is no way for your healthcare provider to know beforehand if you will have side effects from a medicine that you have never tried. Therefore, make sure to let your healthcare provider know if you develop any side effects while taking chlorpromazine or if something "just does not seem right" during treatment. While it may not be a side effect of chlorpromazine, your healthcare provider will be able to diagnose and treat the problem.
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