Drug Interactions With Clozapine

Clozapine Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when clozapine is combined with any of the drugs listed above.
 
Benzodiazepines
Taking clozapine with a benzodiazepine can increase your risk of dangerous side effects. Talk to your healthcare provider before combining these medications.
 
Blood Pressure Medications
Clozapine can cause low blood pressure (hypotension). Your healthcare provider should monitor your blood pressure closely if you take blood pressure medications with clozapine.
 
Certain Antibiotics or Antifungals
Combining clozapine with certain antibiotics or antifungals can increase the level of clozapine in your blood, increasing your risk of clozapine side effects. Your healthcare provider may need to lower your clozapine dose to prevent this interaction from occurring.
 
Certain Anticonvulsants
Taking clozapine with certain anticonvulsants (seizure medications) can decrease the level of clozapine in your blood, perhaps making it less effective. Your healthcare may need to increase your clozapine dosage to prevent this.
 
Certain Antidepressants
Combining clozapine with certain antidepressants can increase the level of clozapine in your blood, which may increase your risk of clozapine side effects. Your healthcare provider may need to lower your clozapine dose to prevent this interaction from occurring.
 
Certain Arrhythmia Medications
Taking clozapine with certain arrhythmia medications can increase the level of both medications in your blood, potentially increasing your risk of side effects. Your healthcare provider may need to lower your doses of these medications to prevent this.
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Clozapine Drug Information

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