Drug Interactions With Clozapine

Cimetidine
If clozapine is taken with cimetidine, this can increase the level of clozapine in your blood, potentially increasing your risk of clozapine side effects. Your healthcare provider may need to lower your clozapine dose to prevent this interaction from occurring.
 
Nicotine
Taking clozapine with nicotine can decrease the level of clozapine in your blood, perhaps making it less effective. Your healthcare may need to increase your clozapine dosage if you smoke.
 
Phenothiazines
Combining clozapine with a phenothiazine can increase the level of both medications in your blood, potentially increasing your risk of side effects. Your healthcare provider may need to lower your doses of both medications to prevent this.

QT-Prolonging Medications
There have been reports of a certain change in heart rhythm (known as QT prolongation) in people taking clozapine. This heart rhythm change can be dangerous. Check with your healthcare provider before combining clozapine with other QT-prolonging medications.
 
Quinidine
Taking clozapine with quinidine can increase the level of both medications in your blood, possibly increasing your risk of side effects. Your healthcare provider may need to lower your doses of both medications to keep this interaction from occurring.
 
Rifamycin Antibiotics
Taking clozapine with a rifamycin antibiotic can decrease the level of clozapine in your blood, perhaps making it less effective. Your healthcare may need to increase your clozapine dosage to prevent this.
 

Final Thoughts on Drug Interactions With Clozapine

Not all drug interactions with clozapine were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about the specific drug interactions that may apply to you.
 
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Clozapine Drug Information

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