Schizophrenia Home > Drug Interactions With Chlorpromazine

Some of the drugs that can potentially cause drug interactions with chlorpromazine include barbiturates, narcotics or opiates, tricyclic antidepressants, and rifamycin antibiotics. Chlorpromazine drug interactions may alter the levels of some drugs in your blood or increase your risk of side effects like drowsiness or seizures.

An Introduction to Drug Interactions With Chlorpromazine

Chlorpromazine hydrochloride (Thorazine®) can potentially interact with a number of other medicines. Some of these medicines that may lead to chlorpromazine interactions include:
  • Alcohol
  • Barbiturates, including:


    • Amobarbital (Amytal®)
    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
    • Secobarbital (Seconal®)


  • Certain anticonvulsants, including:







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Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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