Schizophrenia Home > Invega and Diabetes

There are a number of possible side effects with Invega, and diabetes is one of the more serious side effects that have been reported. Although the connection between Invega and diabetes is not fully understood, it is known that weight gain (another possible side effect of the drug) is a major risk factor for diabetes. While you are taking Invega, make sure to look out for possible signs of diabetes and to check blood sugar levels regularly.

An Overview of Invega and Diabetes

Invega® (paliperidone) is a prescription medication used to treat schizophrenia and schizoaffective disorder. While many Invega side effects are merely annoying or bothersome, there are a few side effects of Invega that should be taken very seriously. One of these serious side effects is diabetes. Newer "atypical" antipsychotic medications (such as Invega) seem to increase the risk of diabetes. Invega may also worsen preexisting diabetes.

Invega and Diabetes Research

There have been just a few cases of diabetes in people taking Invega. However, since Invega is a new medication, more cases may be reported with time.
It is not entirely clear if Invega is the cause of these cases of diabetes. People with schizophrenia (whether they are taking Invega or not) may be at a higher risk of developing diabetes. Also, diabetes is on the rise in the general population. These factors combined make it unclear whether there is a relationship between Invega and diabetes. However, studies suggest that people taking Invega may be at a higher risk of developing diabetes.

Why Might Invega Cause Diabetes?

It is not entirely clear why Invega might lead to diabetes. Weight gain is a significant risk factor for diabetes (see Diabetes Risk Factors), and weight gain is a common side effect of Invega (see Invega and Weight Gain). Invega may also have direct effects on blood sugar, through unknown mechanisms. Invega also might make diabetes more obvious in people with previously undiagnosed diabetes.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
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