Schizophrenia Home > Stelazine and Insomnia

Is there a connection between Stelazine and insomnia? Although the exact percentage was not reported, people taking the drug have reported insomnia as a side effect. However, it is difficult to know if the insomnia is due to Stelazine or to the condition being treated. This is because a number of people with schizophrenia or anxiety have reported problems with insomnia.

Stelazine and Insomnia: An Overview

Insomnia is a possible side effect of Stelazine® (trifluoperazine hydrochloride), although the exact percentage of people who developed insomnia while taking the drug was not reported. It is also quite common for Stelazine to cause drowsiness, rather than insomnia.

What Is Insomnia?

People with insomnia have one or more of the following symptoms:
  • Difficulty falling asleep
  • Waking up often during the night and having trouble going back to sleep
  • Waking up too early in the morning
  • Non-refreshing sleep.

Stelazine and Insomnia: Suggestions

For some people taking Stelazine, improving sleep habits can be a cure for insomnia. Tips for better sleep include the following:
  • Keep a regular sleep-wake cycle. Try to go to bed and wake up at the same time every day.
  • Avoid caffeine, alcohol, and nicotine in the four to six hours before bedtime.
  • Refrain from exercise within two hours of bedtime. Exercising five or six hours before bedtime, however, may help you sleep more soundly.


  • Avoid large meals within two hours of bedtime.
  • Refrain from taking a nap later than 3 p.m.
  • Sleep in a dark, quiet room at a comfortable temperature.
  • Do a quiet activity if you can't fall asleep within 20 minutes, and return to bed when you're sleepy.
  • Wind down in the 30 minutes before bedtime with a relaxing pre-sleep ritual, such as a warm bath, soft music, or reading.
(Click Good Sleep Habits for more suggestions.)
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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