Schizophrenia Home > Zyprexa Relprevv Side Effects

Although most people tolerate Zyprexa Relprevv reasonably well, side effects are a possibility. Common problems can include headaches, coughing, and weight gain. In most cases, reactions to the drug are minor and easily treated. However, you should contact your healthcare provider right away if you develop more serious side effects, such as seizures, confusion, or signs of an allergic reaction.

An Introduction to Zyprexa Relprevv Side Effects

Just like any medicine, Zyprexa® Relprevv™ (olanzapine extended-release injection) can cause side effects. However, not everyone who uses the medication will have problems. In fact, most people tolerate it reasonably well. If reactions do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with Zyprexa Relprevv. Your healthcare provider can discuss a more complete list with you.)

Common Side Effects With Zyprexa Relprevv

Zyprexa Relprevv has been studied extensively in clinical trials. In these studies, the side effects that occurred in a group of people using Zyprexa Relprevv were documented and then compared to those that occurred in a similar group of people receiving a placebo (an injection with no active ingredient). As a result, it was possible to see what side effects occurred, how often they appeared, and how they compared to the placebo.
In these studies, the most common Zyprexa Relprevv side effects included:
  • Headache -- in up to 18 percent of people
  • Sleepiness or drowsiness -- up to 13 percent
  • Cough -- up to 9 percent
  • Weight gain -- up to 7 percent
  • Diarrhea -- up to 7 percent
  • Symptoms of the common cold, such as a runny nose or congestion -- up to 7 percent
  • Dry mouth -- up to 6 percent
  • Increased appetite -- up to 6 percent
  • Vomiting -- up to 6 percent
  • Back pain -- up to 5 percent
  • Nausea -- up to 5 percent.
Other common side effects, occurring in 2 percent to 4 percent of people, included:
  • Fatigue
  • Toothache
  • Tooth infection
  • Ear pain
  • Muscle stiffness
  • Upper respiratory tract infection
  • Dizziness
  • Vaginal discharge
  • Abdominal (stomach) pain
  • Pain at the site of the injection
  • Joint pain
  • Sore throat
  • General pain
  • Muscle spasms
  • Tremor
  • Hearing things that aren't real (auditory hallucinations)
  • Abnormal thoughts
  • Restlessness
  • Increase in blood pressure (hypertension)
  • Increase in liver enzymes
  • Gas
  • Fever
  • Viral infection
  • Heart rhythm changes
  • Abnormal dreams
  • Sleep problems
  • Sneezing
  • Acne
  • Slurred or slowed speech, due to problems controlling muscles that help you talk.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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