Drug Interactions With Prochlorperazine (Cont.)

 
Alcohol
In general, people taking prochlorperazine should avoid alcohol (see Alcohol and Compazine).
 
Barbiturates
Prochlorperazine should not be combined with large doses of barbiturates, due to the increased risk of sedation and other problems.
 
Narcotics and Opiates
Prochlorperazine should not be combined with large doses of narcotics and opiates, due to increased risk of sedation and other problems.
 
Propranolol (Inderal, Inderal LA, InnoPran XL)
Combining prochlorperazine with propranolol may raise the levels of both medications in your blood, increasing your risk of side effects. Talk with your healthcare provider before using these medications together.
 
Seizure Medications
Prochlorperazine may make seizure medications less effective. Your healthcare provider may need to increase your doses of seizure medications.
 
Warfarin (Coumadin, Jantoven)
Prochlorperazine may make warfarin less effective. Your healthcare provider may need to monitor you more closely and adjust your warfarin dosage as necessary.
 

Final Thoughts on Drug Interactions With Prochlorperazine

Not all drug interactions with prochlorperazine were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about the prochlorperazine drug interactions that may apply to you. Because so many medications interact dangerously with prochlorperazine, you should not take any medication (including non-prescription medications) without first talking with your healthcare provider.

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;