Drug Interactions With Prochlorperazine

A number of medications -- including propranolol, narcotics or opiates, and barbiturates -- may potentially cause drug interactions with prochlorperazine. Taking these drugs with prochlorperazine may raise the risk of side effects or decrease the effectiveness of some medicines. To reduce your risk of developing potentially dangerous prochlorperazine drug interactions, make sure to tell your healthcare provider (prior to taking prochlorperazine) about all other medications you are taking.

 

An Introduction to Drug Interactions With Prochlorperazine

Prochlorperazine maleate (Compazine®) can potentially interact with a number of other medicines. Some of these medicines that may lead to prochlorperazine interactions include:
 
  • Alcohol
  • Barbiturates, including:

 

    • Amobarbital (Amytal®)
    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
    • Secobarbital (Seconal®)

 

  • Narcotics or opiates, such as morphine or oxycodone (Oxycontin®)
  • Propranolol (Inderal®, Inderal LA®, InnoPran XL®)
  • Seizure medications
  • Warfarin (Coumadin®, Jantoven®).
     

Interactions With Prochlorperazine Explained

The following sections explain in detail the potentially negative interactions that can occur when prochlorperazine is combined with any of the drugs listed above.
(Drug Interactions With Prochlorperazine Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;