Precautions and Warnings With Prochlorperazine

It is important to know that prochlorperazine may cause increased sensitivity to the sun, tardive dyskinesia, or neuroleptic malignant syndrome in some people. Before taking prochlorperazine, you should let your healthcare provider know if you have difficulty passing urine, any breathing problems, glaucoma, or an enlarged prostate, among other conditions. Ask your healthcare provider about any prochlorperazine precautions and warnings that apply to you.

Prochlorperazine: What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking prochlorperazine maleate (Compazine®) if you have:
Also let your healthcare provider know if you:
  • Are pregnant or thinking of becoming pregnant
  • Are breastfeeding
  • Drink alcohol.
You should also be sure to tell your healthcare provider about all other medicines you are taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Some Prochlorperazine Precautions and Warnings

Some warnings and precautions to be aware of with prochlorperazine include:
  • Prochlorperazine should not be used in children with Reye's syndrome. Symptoms of Reye's syndrome usually develop after a viral infection and can include:


    • Vomiting
    • Personality changes such as irritability or combativeness
    • Disorientation or confusion
    • Seizures.


  • Prochlorperazine can cause a life-threatening condition called neuroleptic malignant syndrome (NMS). Some symptoms of NMS include:


    • A high fever
    • Stiff muscles
    • Confusion
    • Irregular pulse or blood pressure
    • A fast heart rate (tachycardia)
    • Sweating
    • Irregular heart rhythms (arrhythmias).


  • Tell your healthcare provider right away if think you might have NMS.
  • Prochlorperazine can cause tardive dyskinesia, a condition involving unusual, uncontrollable body or face movements. The condition can become permanent (even if prochlorperazine is stopped). The best way to prevent it from becoming permanent is to tell your healthcare provider right away if you notice any abnormal movements (including abnormal movements of the tongue) while taking prochlorperazine.
  • Prochlorperazine can impair your mental or physical abilities to drive a car or operate heavy machinery. Make sure you know how prochlorperazine affects you before you do any activities that require mental concentration or physical coordination. Combining prochlorperazine with medications or substances that cause drowsiness (such as narcotics, alcohol, or barbiturates) can be dangerous (see Alcohol and Compazine).
  • Let your healthcare provider know if you have breathing problems, as prochlorperazine could worsen these problems.
  • Prochlorperazine can increase your sensitivity to the sun, increasing your risk of sunburn. You should use sunscreen before sun exposure while taking prochlorperazine.
  • Prochlorperazine is considered a pregnancy Category C medication. This means that it may not be safe to use during pregnancy. Be sure to talk with your healthcare provider about the risks and benefits of using prochlorperazine during pregnancy (see Compazine and Pregnancy).
  • It is not known if prochlorperazine passes through breast milk. Therefore, if you are breastfeeding or plan to start breastfeeding, be sure to talk with your healthcare provider about using prochlorperazine (see Compazine and Breastfeeding for more information).
  • Prochlorperazine can interact with certain other medications (see Drug Interactions With Prochlorperazine).
Drink Less Alcohol

Prochlorperazine Maleate

Referring Pages:
Terms of Use
Advertise with Us
Contact Us
About eMedTV
Privacy Policy
Copyright © 2006-2020 Clinaero, Inc.
eMedTV serves only as an informational resource. This site does not dispense medical advice or advice of any kind. Site users seeking medical advice about their specific situation should consult with their own physician. Click Terms of Use for more information.