Prochlorperazine Dosing

For those who are being treated for schizophrenia with prochlorperazine, dosing typically starts at 5 mg or 10 mg three or four times a day. For the treatment of nausea or vomiting, the recommended starting prochlorperazine dose is also 5 mg to 10 mg three or four times daily (or one 25 mg rectal suppository twice a day). The suggested prochlorperazine dosage for anxiety treatment is 5 mg three or four times daily.

 

An Introduction to Prochlorperazine Dosage

The dose of prochlorperazine maleate (Compazine®) that your healthcare provider recommends will vary depending on a number of factors, including:
 
  • The medical condition being treated
  • Your age and weight (for children)
  • The form of prochlorperazine (tablet, suppository, or injection)
  • Other medical conditions you may have
  • Other medications you may be currently taking.
     
As always, do not adjust your prochlorperazine dosage unless your healthcare provider specifically instructs you to do so.
 
Prochlorperazine Dosing for Schizophrenia
The recommended starting prochlorperazine dose for schizophrenia is 5 mg or 10 mg three or four times daily (though people under medical supervision in a hospital may start at higher dosages). Your healthcare provider may need to adjust your prochlorperazine dose, depending on how you react to the medication.
 
Prochlorperazine Dosing for Nausea and Vomiting
The recommended prochlorperazine dose for severe nausea and vomiting is 5 mg to 10 mg three to four times daily. For prochlorperazine rectal suppositories, the recommended dose is one 25 mg suppository inserted rectally twice daily.
 
Prochlorperazine Dosing for Anxiety
The usual prochlorperazine dose for anxiety is 5 mg three to four times daily. It should not be used at doses higher than 20 mg per day or for longer than 12 weeks.
 
(Prochlorperazine Dosing Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;