When and How to Take Prochlorperazine

Some general considerations for when and how to take the medication include:
  • Prochlorperazine comes in tablet and rectal suppository forms. It is also available in an injectable form.
  • The suppositories can be especially useful for people with very severe nausea and vomiting who have difficulty swallowing (or "keeping down") a tablet.
  • Do not take prochlorperazine rectal suppositories by mouth. Be sure to remove the foil or plastic packaging before inserting rectally.
  • You can take the tablets with or without food.
  • If you take prochlorperazine on a daily basis, you should take it at the same times each day to maintain even levels of the drug in your blood.
  • For the medication to work properly, it must be used as prescribed. It will not work if you stop using it.


The dose of prochlorperazine that your healthcare provider recommends will vary depending on a number of factors, including:
  • The medical condition being treated
  • Your age and weight (for children)
  • The form of prochlorperazine (tablet, suppository, or injection)
  • Other medical conditions you may have
  • Other medications you may be currently taking.
As with any medication, do not adjust your dose unless your healthcare provider specifically instructs you to do so.
(Click Prochlorperazine Dosing for more information.)

Drug Interactions

Prochlorperazine can potentially interact with a number of other medicines.
(Click Drug Interactions With Prochlorperazine for more information.)
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