Side Effects of Prochlorperazine

Side Effects With Prochlorperazine to Report

There are a number of side effects with prochlorperazine that you should report to your healthcare provider. These include but are not limited to:
  • An irregular heart rhythm (arrhythmia)
  • Low blood pressure (hypotension)
  • Very severe constipation
  • High blood sugar (hyperglycemia) or low blood sugar (hypoglycemia)
  • Yellowing of the eyes or skin (jaundice)
  • Breast changes, such as breast enlargement or breast discharge
  • A painful erection of the penis that does not go away (known medically as priapism)
  • Worsening of psychotic symptoms
  • "Extrapyramidal symptoms," such as:


    • Unusual body, facial, or tongue movements
    • Muscle tension or contractions
    • Feelings of internal restlessness or jitteriness


  • Seizures
  • Signs or symptoms of neuroleptic malignant syndrome, which can include:


    • A high fever
    • Stiff muscles
    • Confusion
    • Irregular pulse or blood pressure
    • An increased heart rate (tachycardia)
    • Sweating
    • Irregular heart rhythms (arrhythmias)


  • Signs of an allergic reaction, including unexplained rash, hives, itching, unexplained swelling, wheezing, or difficulty breathing or swallowing.

A Summary of Prochlorperazine Side Effects

It is possible that you may experience some or none of the prochlorperazine side effects explained above. Unfortunately, there is no way for your healthcare provider to know beforehand if you will have side effects from a medicine that you have never tried. Therefore, make sure to let your healthcare provider know if you develop any side effects while taking prochlorperazine or if something "just does not seem right" during treatment. While it may not be a side effect of prochlorperazine, your healthcare provider will be able to diagnose and treat the problem.
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Prochlorperazine Maleate

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