Drug Interactions With Quetiapine

When certain medications are taken together, there is a potential for negative drug interactions. With quetiapine, these interactions can decrease the effectiveness of the medications, increase the drug levels in your blood, or cause the drugs to lose their effectiveness. Medicines that can cause drug interactions with quetiapine include cimetidine, lorazepam, and phenytoin. To prevent these interactions from occurring, your healthcare provider may adjust your dosages.

Drug Interactions With Quetiapine: An Introduction

Quetiapine fumarate (Seroquel^®) can potentially interact with a number of other medicines. Some of the medicines that may lead to drug interactions with quetiapine include:

Alcohol
Certain antibiotics or antifungals, including:
- Clarithromycin (Biaxin^®)
- Erythromycin (Ery-Tab^®)
- Isoniazid (Nydrazid^®)
- Itraconazole (Sporanox^®)
- Ketoconazole (Nizoral^®)
- Miconazole
- Telithromycin (Ketek^®)

Cimetidine (Tagamet^®)
Divalproex (Depakote^®, Depakote ER^®)
Lorazepam (Ativan^®)
Medications that cause a certain change in heart rhythm (see QT-Prolonging Medications for a list)
Phenytoin (Dilantin^®, Phenytek^®)
Thioridazine (Mellaril^®).

More Information on Interactions With Quetiapine

The following sections explain in detail the potentially negative interactions that can occur when quetiapine is combined with any of the drugs listed above.

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