Saphris Dosage

When used to treat bipolar disorder, people often start with a dose of Saphris 10 mg, twice daily. However, this amount can be decreased if bothersome side effects occur. People taking the drug for schizophrenia start with a smaller dosage. It is important to keep the tablets in the blister packaging until just before use.

An Introduction to Dosing With Saphris

The dosage of Saphris® (asenapine) your healthcare provider recommends will vary, depending on a number of factors, including:
  • The medical condition being treated (schizophrenia or bipolar disorder)
  • How you respond to Saphris
  • Other medications you may be taking
  • Other medical conditions you may have.
As is always the case, do not adjust this amount unless your healthcare provider specifically tells you to do so.

Saphris Dosage for Schizophrenia

The recommended starting dose of Saphris for the treatment of schizophrenia is 5 mg twice daily. If necessary, your healthcare provider may increase your dosage up to 10 mg twice daily, although this may increase the risk of Saphris side effects.

Saphris Dosage for Bipolar Disorder

The recommended dosage of Saphris for the acute treatment of manic or mixed episodes of bipolar disorder is 10 mg twice daily. If necessary, your healthcare provider may decrease the amount to 5 mg twice daily if bothersome side effects occur.
For people combining Saphris with lithium or valproate medications (such as Depakene®, Depakote®, or Depakote ER®), the starting dosage is Saphris 5 mg twice daily. If necessary, your healthcare provider may increase the dosage up to 10 mg twice daily.
As with schizophrenia, Saphris is not approved for long-term bipolar disorder treatment; however, your healthcare provider will likely recommend that you stay on this medication as long as significant benefit is seen.
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Saphris Medication Information

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