Saphris Drug Interactions

Certain medications, such as ciprofloxacin, lidocaine, and QT-prolonging medicines, may cause drug interactions with Saphris. Such reactions can be potentially serious -- even life-threatening -- and could cause dangerous heart rhythms, extreme drowsiness, or lightheadedness. Check with your doctor before combining Saphris with any other medicines, both prescription and nonprescription.

An Overview of Saphris Interactions

Saphris® (asenapine) can potentially interact with several other medications. Some of the medicines that may lead to drug interactions with Saphris include:
 
  • Alcohol or other substances or medications that cause drowsiness
  • Blood pressure medications
  • CYP1A2 inhibitor medications, such as:
     
    • Ciprofloxacin (Cipro®, Cipro® XR)
    • Fluvoxamine (Luvox®, Luvox® CR)
    • Ketoconazole (Nizoral®)
    • Lidocaine
    • Methoxsalen (8-MOP®, Oxsoralen-Ultra®)
    • Mexiletine
    • Norfloxacin (Noroxin®)
    • Ofloxacin (Floxin®)
    • Primaquine
 
  • Medicines that cause a certain change in the heart rhythm known as QT prolongation (see QT-Prolonging Medications for a list of such drugs).
     

Drug Interactions With Saphris Explained

The following sections explain in detail the potentially negative interactions that can occur when Saphris is combined with any of the drugs listed above.
 
Alcohol or Medications That Cause Drowsiness
Combining Saphris with alcohol or medications that cause drowsiness could cause undesirable or even potentially dangerous side effects, such as extreme drowsiness, "passing out," confusion, or impaired breathing.

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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