Seroquel XR Drug Interactions (Cont.)

 
Certain Antibiotics or Antifungals
Taking Seroquel XR with some antibiotics or antifungal medications may increase the level of Seroquel XR in your blood, increasing your risk of Seroquel XR side effects. Your healthcare provider may need to lower your Seroquel XR dosage.
 
Cimetidine (Tagamet)
Taking Seroquel XR with cimetidine may increase the level of Seroquel XR in your blood, increasing your risk of side effects. Your healthcare provider may need to lower your Seroquel XR dosage, although this is not always necessary.
 
Divalproex (Depakote, Depakote ER)
Taking Seroquel XR with divalproex may increase the level of Seroquel XR in your blood, increasing your risk of side effects. Combining these medications can also decrease the level of divalproex in your blood, possibly decreasing its effectiveness. Your healthcare provider may need to lower your Seroquel XR dosage and increase your divalproex dosage.
 
Lorazepam (Ativan)
Taking lorazepam with Seroquel XR can increase the level of lorazepam in your blood, increasing your risk of lorazepam side effects. Your healthcare provider may need to lower your lorazepam dosage.
 
Phenytoin (Dilantin, Phenytek)
Taking Seroquel XR with phenytoin can decrease the level of Seroquel XR in your blood, perhaps making it less effective. Your healthcare provider may need to increase your Seroquel XR dosage.
 
Thioridazine (Mellaril)
Taking Seroquel XR with thioridazine can decrease the level of Seroquel XR in your blood, perhaps making it less effective. Your healthcare provider may need to increase your Seroquel XR dosage.
 

Final Thoughts on Seroquel XR Drug Interactions

It is possible that not every drug interaction with Seroquel XR was discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about the Seroquel XR drug interactions that may apply to you.

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;