Seroquel XR Drug Interactions

Alcoholic Beverages
It is not recommended that you drink alcohol while taking Seroquel XR. Taking alcohol and Seroquel XR together may cause unwanted side effects (see Alcohol and Seroquel).
 
Certain Antibiotics or Antifungals
Taking Seroquel XR with some antibiotics or antifungal medications may increase the level of Seroquel XR in your blood, increasing your risk of Seroquel XR side effects. Your healthcare provider may need to lower your Seroquel XR dosage.
 
Cimetidine (Tagamet)
Taking Seroquel XR with cimetidine may increase the level of Seroquel XR in your blood, increasing your risk of side effects. Your healthcare provider may need to lower your Seroquel XR dosage, although this is not always necessary.
 
Divalproex (Depakote, Depakote ER)
Taking Seroquel XR with divalproex may increase the level of Seroquel XR in your blood, increasing your risk of side effects. Combining these medications can also decrease the level of divalproex in your blood, possibly decreasing its effectiveness. Your healthcare provider may need to lower your Seroquel XR dosage and increase your divalproex dosage.
 
Lorazepam (Ativan)
Taking lorazepam with Seroquel XR can increase the level of lorazepam in your blood, increasing your risk of lorazepam side effects. Your healthcare provider may need to lower your lorazepam dosage.
 
Medications That Cause QT Prolongation
Many medications, including Seroquel XR, have a tendency to cause a change in the heart rhythm known as QT prolongation. If severe enough, this can be fatal. Combining Seroquel XR with other medications with this potential increases the risk. Check with your healthcare provider before combining Seroquel XR with other QT-prolonging medications.
  
Phenytoin (Dilantin, Phenytek)
Taking Seroquel XR with phenytoin can decrease the level of Seroquel XR in your blood, perhaps making it less effective. Your healthcare provider may need to increase your Seroquel XR dosage.
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Seroquel XR Drug Information

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