Precautions and Warnings With Thioridazine

Some Thioridazine Precautions and Warnings

Some warnings and precautions to be aware of with thioridazine include:
  • Thioridazine can cause a life-threatening irregular heart rhythm (arrhythmia) called QT prolongation. Because of this risk, thioridazine should be used only when other antipsychotic medications have failed.
  • Thioridazine can cause a life-threatening condition called neuroleptic malignant syndrome (NMS). Some symptoms of NMS include:


    • A high fever
    • Stiff muscles
    • Confusion
    • Irregular pulse or blood pressure
    • A fast heart rate (tachycardia)
    • Sweating
    • Irregular heart rhythms (arrhythmias).
Tell your healthcare provider right away if think you might have NMS.
  • Thioridazine can cause tardive dyskinesia, a condition involving unusual, uncontrollable body or face movements. The condition can become permanent (even if thioridazine is stopped). The best way to prevent it from becoming permanent is to tell your healthcare provider right away if you notice any abnormal movements (including abnormal movements of the tongue) while taking thioridazine.
  • Thioridazine can impair your mental or physical abilities to drive a car or operate heavy machinery. Make sure you know how thioridazine affects you before you do any activities that require mental concentration or physical coordination. Combining thioridazine with medications or substances that cause drowsiness (such as narcotics, alcohol, or anesthetics for surgery) can be dangerous.
  • Thioridazine can cause a drop in blood pressure (hypotension). This can cause a person to have lightheadedness or dizziness, or to faint. Tell your healthcare provider if you have any of these symptoms when standing. Hypotension can be especially dangerous in people with heart disease or congestive heart failure (CHF). Combining alcohol with thioridazine can also increase the risk of hypotension (see Alcohol and Mellaril).
  • Thioridazine may increase the risk of seizures in some people. Before starting thioridazine, tell your healthcare provider if you have epilepsy or a history of seizures.
  • Thioridazine is considered a pregnancy Category C medication. This means that it may not be safe to take during pregnancy. Be sure to talk with your healthcare provider about the risks and benefits of using thioridazine during pregnancy (see Mellaril and Pregnancy).
  • It is not known if thioridazine passes through breast milk. Therefore, if you are breastfeeding or plan to start breastfeeding, be sure to talk with your healthcare provider about using thioridazine (see Mellaril and Breastfeeding for more information).
  • Thioridazine can interact with certain other medications (see Drug Interactions With Thioridazine).
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Information on Thioridazine

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