Drug Interactions With Ziprasidone

There are a number of medications that may potentially lead to drug interactions with ziprasidone, including carbamazepine, certain anesthetics, pentamidine, and vardenafil. Ziprasidone interactions may increase the risk of a dangerous irregular heart rhythm called QT prolongation or alter the levels of ziprasidone in your blood, among other things. Be sure to talk with your pharmacist or healthcare provider about any ziprasidone drug interactions that may apply to you.

• Alfuzosin (Uroxatral^®)
• Amoxapine
• Apomorphine (Apokyn^®)
• Avanafil (Stendra™) 
• Carbamazepine (Epitol^®, Equetro™, Tegretol^®, Tegretol XR^®)
• Chloroquine (Aralen^®)
• Certain anesthetics
• Certain antibiotics or antifungals, including:

• Ciprofloxacin (Cipro^®, Cipro XR^®)
• Clarithromycin (Biaxin^®, Biaxin XL^®)
• Erythromycin (Ery-Tab^®)
• Gemifloxacin (Factive^®)
• Ketoconazole (Nizoral^®)
• Levofloxacin (Levaquin^®)
• Mefloquine (Lariam^®)
• Moxifloxacin (Avelox^®)
• Norfloxacin (Noroxin^®)
• Ofloxacin (Floxin^®)
• Telithromycin (Ketek^®)
• Troleandomycin (Tao^®)

• Certain arrhythmia medications, including:

• Amiodarone (Cordarone^®)
• Disopyramide (Norpace^®, Norpace CR^®)
• Dofetilide (Tikosyn^®)
• Flecainide (Tambocor^®)
• Ibutilide (Corvert^®)
• Procainamide (Procanbid^®)
• Propafenone (Rythmol^®)
• Quinidine
• Sotalol (Betapace^®)

• Certain phenothiazine medications, including:

• Chlorpromazine (Thorazine^®)
• Fluphenazine (Prolixin^®)
• Perphenazine (Trilafon^®)
• Prochlorperazine (Compazine^®)
• Trifluoperazine (Stelazine^®)
• Thioridazine (Mellaril^®)

• Cisapride (Propulsid^®)
• Clozapine (Clozaril^®, FazaClo^®)
• Cyclobenzaprine (Flexeril^®, Fexmid™)
• Dasatinib (Sprycel^®)
• Dolasetron (Anzemet^®)
• Droperidol (Inapsine^®)
• Haloperidol (Haldol^®)
• Maprotiline (Ludiomil^®)
• Methadone (Dolophine^®)
• Octreotide (Sandostatin^®)
• Olanzapine (Zyprexa^®, Symbyax^®)
• Ondansetron (Zofran^®, Zuplenz™) 
• Paliperidone (Invega^®)
• Palonosetron (Aloxi^®)
• Pentamidine (NebuPent^®, Pentam^®)
• Pimozide (Orap^®)
• Ranolazine (Ranexa^®)
• Risperidone (Risperdal^®)
• Sunitinib (Sutent^®)
• Tacrolimus (Prograf^®)
• Vardenafil (Levitra^®, Staxyn™)
• Vorinostat (Zolinza^®).