Zyprexa Relprevv Drug Interactions

Zyprexa Relprevv Drug Interactions Explained

The following sections explain in detail the potentially negative reactions that can occur when any of the drugs mentioned above are combined with Zyprexa Relprevv.
 
Alcohol
Drinking alcohol during Zyprexa Relprevv treatment could cause unwanted side effects, such as extreme drowsiness, dizziness, or lightheadedness. This would make it unsafe to perform tasks that require mental alertness, such as driving or operating heavy machinery. You should generally not drink alcohol during Zyprexa Relprevv treatment unless your healthcare provider tells you it is okay to do so.
 
Anticholinergic Medications
Anticholinergic medicines are a class of drugs used to treat a wide variety of conditions, such as urinary incontinence, chronic obstructive pulmonary disease (COPD), and hay fever. Combining Zyprexa Relprevv with an anticholinergic medicine could increase the risk for certain side effects, including dry mouth, dry eyes, constipation, and urinary retention (difficulty passing urine).
 
Blood Pressure Medications
Zyprexa Relprevv can cause low blood pressure. If you use it with blood pressure medicines, your healthcare provider may need to monitor your blood pressure more closely to make sure your blood pressure doesn't drop too low.
 
Certain Medications to Treat Parkinson's Disease
Zyprexa Relprevv could make certain medicines used in the treatment of Parkinson's disease less effective. Your healthcare provider will monitor you closely and carefully adjust your medication doses if you use these medications together.
 
CYP 1A2 Inducer Medications
The liver breaks down Zyprexa Relprevv using enzymes known as CYP 1A2 enzymes, and some medications known as CYP 1A2 inducers can increase the activity of these enzymes. Thus, combining Zyprexa Relprevv with one of these drugs may decrease the level of Zyprexa Relprevv in your body, possibly making it less effective. Your healthcare provider may need to monitor you more closely if you combine Zyprexa Relprevv with a CYP 1A2 inducer to make sure it is working for you. You may need a higher Zyprexa Relprevv dose.
 
CYP 1A2 Inhibitor Medications
The liver breaks down Zyprexa Relprevv using enzymes known as CYP 1A2 enzymes, and some medications known as CYP 1A2 inhibitors can decrease the activity of these enzymes. Thus, combining Zyprexa Relprevv with one of these drugs may increase the level of Zyprexa Relprevv in your body, increasing your risk for side effects. You may need a lower Zyprexa Relprevv dose if you are also taking a CYP 1A2 inhibitor.
 
CYP 2D6 Inhibitor Medications
The liver breaks down Zyprexa Relprevv using enzymes known as CYP 2D6 enzymes, and some medications known as CYP 2D6 inhibitors can decrease the activity of these enzymes. Thus, combining Zyprexa Relprevv with one of these drugs may increase the level of Zyprexa Relprevv in your body, increasing your risk for side effects. If you combine Zyprexa Relprevv with a CYP 2D6 inhibitor, your healthcare provider may choose to monitor you more closely. However, it is usually not necessary to adjust your medication dose.
 
Diazepam
Combining Zyprexa Relprevv with diazepam can increase your risk for low blood pressure, especially when rising from a seated or lying-down position. Talk to your healthcare provider about this interaction before using these medications together. 
 
Medications That Cause Drowsiness
Combining Zyprexa Relprevv with other medications that cause drowsiness may increase your risk for side effects, such as extreme drowsiness, dizziness, or lightheadedness. This could make it unsafe to perform tasks that require mental alertness, such as driving or operating heavy machinery.
 
Metoclopramide
Combining Zyprexa Relprevv with metoclopramide could increase your risk for serious movement disorders, including a movement disorder known as tardive dyskinesia. It could also increase your risk for neuroleptic malignant syndrome (NMS), a rare but life-threatening neurological disorder associated with antipsychotic use. In general, these medications should not be used together if at all possible.
 
Omeprazole
Omeprazole may decrease the level of Zyprexa Relprevv in your blood, possibly making it less effective. Talk to your healthcare provider before taking omeprazole during Zyprexa Relprevv treatment. 
 
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