Zyprexa Relprevv Warnings and Precautions

Specific Precautions and Warnings for Zyprexa Relprevv

Some warnings and precautions to be aware of prior to using this drug include the following:
  • Zyprexa Relprevv has the potential to cause a reaction called post-injection delirium sedation syndrome, which occurs if drug levels in your bloodstream rise too quickly. This reaction is most likely to occur within the first three hours of each dose. Therefore, you must receive your dose in a specially registered healthcare facility, such as a hospital or clinic that has access to emergency services. You must also remain at the healthcare facility for at least three hours after your injection, so you can be closely monitored.

    When you are able to leave, someone must be with you in case you develop this side effect. You should also not perform any activities that require mental alertness, such as driving or operating heavy machinery the day you receive your injection. Seek immediate medical care if you have signs of post-injection delirium sedation syndrome, such as:
    • Sedation
    • Dizziness
    • Feeling confused or disoriented
    • Slurred speech
    • Problems walking
    • Weakness
    • Agitation, irritability, restlessness, or anxiety
    • High blood pressure
    • Seizures
    • Loss of consciousness.
  • Antipsychotic medications, such as Zyprexa Relprevv, may increase the risk of strokes and death when used to treat psychosis (such as hallucinations or delusions) caused by dementia. No antipsychotic is approved to treat the behavioral symptoms of dementia, including Zyprexa Relprevv.
  • It is important that you contact your healthcare provider or seek immediate medical help if you have thoughts of suicide or harming yourself or others.
  • Like other antipsychotic medications, Zyprexa Relprevv may cause a rare but life-threatening problem known as neuroleptic malignant syndrome (NMS). Seek immediate medical attention if you develop signs of NMS, which may include:
    • A high fever or sweating
    • Confusion
    • Stiff or rigid muscles
    • A fast or irregular heartbeat (pulse)
    • An irregular blood pressure.
  • Antipsychotic medications, including Zyprexa Relprevv, can cause a potentially irreversible movement disorder known as tardive dyskinesia. Tardive dyskinesia involves uncontrollable facial, tongue, or body movements. Although the risk for tardive dyskinesia generally increases the longer you are treated with antipsychotics, it can occur at any time.

    There is no treatment for tardive dyskinesia, and it may not be reversible, even if Zyprexa Relprevv is stopped. Tell your healthcare provider if you experience any abnormal movements during treatment with this or any other antipsychotic. 
  • Zyprexa Relprevv can increase blood glucose (blood sugar) levels, which could worsen or cause diabetes (see Zyprexa and Diabetes). Your healthcare provider will check your blood sugar levels before you start this medication and periodically throughout treatment. Let your healthcare provider know if you have signs of high blood glucose (known medically as hyperglycemia), such as:
    • Increased thirst
    • Frequent urination
    • Increased appetite
    • Weakness
    • Confusion
    • A fruity smell to your breath.
  • This medication can increase your cholesterol and triglycerides, which can increase your risk for other problems, including heart disease and strokes. Your healthcare provider will monitor your cholesterol before treatment, and periodically during treatment. You may need to take other medicines to help lower your cholesterol if it becomes too high.
  • Many people who are treated with Zyprexa Relprevv find they gain weight. In clinical studies involving olanzapine (the active ingredient in Zyprexa Relprevv), the average weight gain was 5.7 pounds. You may gain more or less weight than this. Talk to your healthcare provider about ways to help maintain your weight during treatment, such as eating a well-balanced, healthy diet and exercising.
  • This medication can cause a drop in blood pressure when rising from a seated or lying position (known medically as orthostatic hypotension). This could cause you to become dizzy, lightheaded, or faint. Make sure you change positions slowly and, if you do feel lightheaded, dizzy, or faint, lie down until you feel better.
  • Zyprexa Relprevv may increase the level of prolactin, a hormone in the body. High prolactin levels can cause a variety of effects, such as enlarged breasts, erectile dysfunction, and menstrual changes or milky breast discharge in women. High prolactin levels can also increase the risk for osteoporosis.
  • Zyprexa Relprevv may decrease white blood cell counts, which could increase your risk for developing an infection. Tell your healthcare provider if you develop signs of infection during treatment, such as:
  • This medication can cause significant sedation, which could affect your thinking, judgment, and motor skills. Do not perform any activities that require mental alertness, such as driving, operating heavy machinery, or making important decisions, until you know how this medication affects you.
  • There have been reports of people having seizures while being treated with Zyprexa Relprevv. Make sure your healthcare provider knows if you have a history of seizures before you use this medicine.
  • Zyprexa Relprevv may cause difficulty swallowing, which could cause you to inhale food or liquids (this is known as aspiration). Aspiration may increase the risk for pneumonia in certain people, especially those who have advanced dementia. If you have difficulty swallowing while using this medication, let your healthcare provider know.
  • You may become overheated more easily during Zyprexa Relprevv treatment. Therefore, you should be especially careful when doing activities that could increase your body temperature, such as exercising or being in the heat. Being dehydrated (which can happen if you don't drink enough fluids or have diarrhea or vomiting) can also cause you to become overheated, so make sure to drink plenty of fluids to remain hydrated during treatment. Let your healthcare provider know if you have signs of dehydration, such as:
    • Dry mouth
    • Thirst
    • Feeling very hot
    • A decrease in the amount you urinate.
  • Zyprexa Relprevv should be used cautiously in people with certain medical conditions, such as narrow-angle glaucoma, an enlarged prostate, or a history of bowel obstruction or blockage. It could make these conditions worse. This medication may also not be safe for people who recently had a heart attack or have uncontrolled heart disease, and should be used cautiously in people with these conditions.
  • This medication passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to receiving the drug (see Zyprexa Relprevv and Breastfeeding).
  • Zyprexa Relprevv is a pregnancy Category C medication, which means it may not be safe for use during pregnancy, although the full risks are currently unknown (see Zyprexa Relprevv and Pregnancy).
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Zyprexa Relprevv Medication Information

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