Zyprexa Relprevv

Zyprexa Relprevv is a drug used to treat schizophrenia. This long-acting medication works by blocking or lessening the effects of certain chemicals in the brain. It comes in the form of an injection that is administered by a healthcare provider every two to four weeks. Although most people tolerate it well, side effects can still occur, such as headaches, sedation, and coughing.

What Is Zyprexa Relprevv?

Zyprexa® Relprevv™ (olanzapine extended-release injection) is a long-acting prescription medication approved to treat schizophrenia. It belongs to a group of medicines known as atypical antipsychotics.
(Click Zyprexa Relprevv Uses for more information, including possible off-label uses.)

Who Makes This Medication?

Zyprexa Relprevv is manufactured by Eli Lilly and Company.

Clinical Effects

Zyprexa Relprevv has been shown to reduce symptoms of schizophrenia in clinical studies. In these studies, people with schizophrenia given an injection of Zyprexa Relprevv every two to four weeks had a greater reduction in their symptoms after eight weeks than people given a placebo (an injection with no active ingredient). 

How Does Zyprexa Relprevv Work?

Zyprexa Relprevv belongs to a group of medicines known as atypical antipsychotics (also called second-generation antipsychotics). It is thought to work by blocking the action of dopamine, a neurotransmitter (chemical) in the brain that is believed to be elevated in people with schizophrenia.
Like other atypical antipsychotics, Zyprexa Relprevv also blocks the action of serotonin, another brain chemical that may be involved in schizophrenia symptoms. By blocking dopamine and serotonin, Zyprexa Relprevv helps restore the natural balance of these chemicals in the brain.
Zyprexa Relprevv is given as an injection into a muscle. After each dose, the medication slowly leaves the body, allowing for once- or twice-a-month dosing.
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Zyprexa Relprevv Medication Information

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