Zyprexa Dosage

Zyprexa Dosage for Injectable Forms

Short-acting Zyprexa injection is used to treat agitation due to schizophrenia or bipolar disorder and is typically used in dosages ranging from 2.5 to 10 mg injected intramuscularly (into a muscle) as needed to control the agitation, up to 30 mg per day.
The newest form of Zyprexa (long-acting Zyprexa Relprevv™ injection) is approved to treat schizophrenia. The dosage is usually calculated using the patient's current oral Zyprexa dosage (since most people starting Zyprexa Relprevv are switching from an oral form of Zyprexa). Zyprexa Relprevv doses range from 150 mg every two weeks (or 300 mg every four weeks) up to 300 mg every two weeks. This form of Zyprexa is given as an injection into the gluteal muscle.
Because Zyprexa Relprevv can cause serious side effects (such as a coma or delirium) shortly after the injection, you must stay at the healthcare facility under the observation of your healthcare provider for at least three hours after each injection.

General Information on Dosing With Zyprexa

Some considerations to keep in mind when taking Zyprexa include the following:
  • Zyprexa is available in several forms, including regular tablets and tablets that are meant to dissolve rapidly in the mouth. These are called Zyprexa Zydis® tablets.
  • Regular Zyprexa tablets should be taken with a glass of water. Zyprexa Zydis tablets do not need to be taken with water.
  • Your dosage can be taken with or without food.


  • A long-acting injection form (known as Zyprexa Relprevv) is available and is given just once every two or four weeks. A short-acting injection form is also available. 


  • Oral forms of this medication should be taken at the same time each day to maintain an even level in your blood.
  • If Zyprexa causes bothersome drowsiness or dizziness for you, ask your healthcare provider if you can take your dose at bedtime to decrease these side effects.
  • For the medicine to work properly, it must be taken as prescribed. Zyprexa will not work if you stop taking it.
  • If you are unsure about anything related to your dosage or Zyprexa dosing in general, talk with your doctor, nurse, or pharmacist. Do not stop taking this drug without first discussing it with your healthcare provider (see Withdrawal From Zyprexa).
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Zyprexa Medication

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